Previous research has explored the therapeutic effect of anti-RANKL antibody (500 μg/mL) with or without microRNA 146a (miR-146a) (100 nM) towards C57/BL6 wild-type (WT) mice and TLR2-/-TLR4-/- (TLR2/4 KO) peri-implantitis mice models. The gene discussed is TLR4; the disease is Peri-Implantitis.