STK10 and neoplasm: While the upregulation of ICD responses within the tumor microenvironment further stimulates the immune system—such as by promoting dendritic cell (DC) maturation and antigen presentation—STK10 concurrently activates inhibitory immune cells, including myeloid-derived suppressor cells (MDSCs) and M2 macrophages, which counteract the immune activation induced by ICD upregulation.