LRRK2 and Parkinson disease: Whether DA neurons may be similarly affected by VPS35 mutations in PD has not been examined, however, multiple other mutations associated with neurodegenerative diseases, potentially including LRRK2 G2019S, appear to promote microglia-mediated synapse loss (Penney et al., 2024; Lall et al., 2021; Zhang et al., 2022; Ayala et al., 2024).