Among them, APOE4 remains by far the strongest and most prevalent genetic risk of AD since it has a great influence on two hallmark pathological proteins by modulating the formation of amyloid-β peptide (Aβ) plaques and neurofibrillary tangles containing hyperphosphorylated tau protein (Serrano-Pozo et al., 2021). Here, MAPT is linked to Alzheimer disease.