In addition to hippocampal atrophy, GMV loss in temporal and parietal lobes, right caudate nucleus, insula, right parietal operculum, the right precuneus, and the cerebellum bilaterally were also reported in APOE4 carriers in patients with MCI (Goni et al., 2013; Spampinato et al., 2011). Here, APOE is linked to hippocampal atrophy.