IL1B and periodontitis: Specifically, combinations such as MMP-8 with IL-1β, IL-1β with IL-6, or MMP-8 with IL-6 correctly identified 78%–81% of patients with periodontitis and excluded 85%–88% of non-periodontitis participants (Blanco-Pintos et al., 2023; Cennamo et al., 2024).