There is an increased cardiovascular risk, increased prevalence of metabolic syndrome, and diagnoses of comorbid diabetes mellitus have also been seen in RA patients with abnormal CRP levels32-34.There is a reported infiltration of the blood-brain barrier by elevations in mCRP secondary to autoimmune conditions like RA. This risks neuroinflammation and a possible progression to Alzheimer’s disease35 indicating the significance of CRP monitoring in patients with RA. This evidence concerns the gene CRP and metabolic syndrome.