POLE and colorectal carcinoma: When examining the distribution of CNTNAP5 mutations within the TCGA CRC dataset, a notable association was observed with POLE‐mutant (80%, eight out of 10 patients) and MSI subtypes (25.8%, 16 out of 62 patients), in contrast to genome stable (0%, none out of 58 patients) or copy number instability (3.4%, 11 out of 328 patients) (Figure S2B).