Likewise, variants rs904589/ANKRD65, rs145378993/ANKRD65, rs13374146/TTLL10, rs1320571/TTLL10, rs4333796/RNF223, rs6690013/SCNN1D and rs2228579/SCNN1D when checked for T2DM showed no/negative (P > 0.05) association with T2DM in the target population. The gene discussed is RNF223; the disease is type 2 diabetes mellitus.