Similarly, two French Canadian brothers with SCAR2 caused by a homozygous mutation in PMPCA p.(Val256Met), presented with different severity of gait impairment, dysarthria, dysmetria and distal atrophy without intellectual deficiency.3 On the other hand, one reported extremely severe clinical features with diffuse parenchymal volume loss as viewed on brain magnetic resonance imaging (MRI) with PMPCA variants. Here, PMPCA is linked to Intellectual disability.