It is known that elevated blood pressure is closely related to plaque formation, and 25-hydroxyvitamin D can inhibit the acetylation and oxidation of LDL in macrophages, reduce foam cell formation, suppress the expression of endoplasmic reticulum-downregulated scavenger receptor A1, decrease intracellular cholesterol deposition, and exert an anti-plaque formation effect.18 In addition, vascular smooth muscle cells and endothelial cells both express vitamin D receptors, and vitamin D has a good inhibitory effect on arteriosclerosis. The gene discussed is VDR; the disease is arteriosclerosis.