These diseases share a common underlying pathophysiology, with elevated IL-5 and eosinophilic inflammation being evident in both, compared to that in health,45,46 as well as common trigger factors, such as aspirin and nonsteroidal anti-inflammatory therapy in those with aspirin-exacerbated respiratory disease, otherwise termed nonsteroidal therapy–exacerbated respiratory disease.47 This evidence concerns the gene IL5 and respiratory system disorder.