The ACTN2 gene (major Z-disc cross-linking protein) is of particular interest as variants within this gene have been linked to diverse cardiac phenotypes such as HCM, dilated cardiomyopathy (DCM), LV non-compaction (LVNC), and SCD (Supplementary File 3) (58–61). This evidence concerns the gene ACTN2 and familial dilated cardiomyopathy.