Adult-onset Still’s Disease: Phase II study indicated a favorable safety profile with preliminary efficacy (121)CAR T Cell Related Cytokine Release Syndrome and HLH-like Syndrome: Ongoing early Phase I study (NCT05306080).NLRC4 Mutation and XIAP Deficiency: Ongoing Phase III studies (NCT03113760, NCT03512314). This evidence concerns the gene XIAP and adult-onset Still disease.