Sevoflurane-induced cognitive dysfunction: Preclinical study demonstrated reduction of caspase-1, IL-1β, IL-18 and NLRP3 inflammasome activation, ameliorated learning ability impairment, and reversed the mitophagy flux dysfunction (144)Sepsis-induced acute kidney injury: Preclinical study showed decrease expression of Caspas-1, NLRP-1, IL-1β, IL-18, and GSDMD in renal tissues (145). The gene discussed is IL18; the disease is acute kidney injury.