Effective management of hypertension is crucial for reducingthis burden; thus, research on advancing hypertension therapy andsuggesting novel pharmaceutical interventions plays a vital role.Among these interventions, AT1R antagonists, with their prototypelosartan, have shown promise due to their targeted action on RAS.Our research highlights the multifaceted role of losartan and itsanalogues in mitigating hypertension and related complications. Here, AGTR1 is linked to Hypertension.