Dysfunction of the glymphatic system in neurodegenerative diseases hinders the removal of pathogenic proteins like Aβ, leading to further aggregation.135 This disruption exacerbates neuroinflammation and oxidative stress, thereby driving disease progression.136,137 Recent evidence suggests that reactive astrocytes may also release GFAP through exocytosis, secreting small vesicles into extracellular space. The gene discussed is GFAP; the disease is neurodegenerative disease.