GFAP and early-onset autosomal dominant Alzheimer disease: Notably, this modification has been associated with several auto-immune or inflammatory conditions such as rheumatoid arthritis or multiple sclerosis, but not with Alzheimer’s disease.72,73 Furthermore, the single cysteine in the GFAP sequence might be subject to lipoxidation, potentially impacting the assembly of GFAP in the intermediate filament network.74