For differentiating frontotemporal dementia from cognitively unimpaired or non-neurodegenerative impairment, plasma NfL was quite accurate as corroborated by Sarto et al.156 in a study involving 385 individuals from Alzheimer’s disease and other cognitive disorders unit (Barcelona), with AUCs of 0.90 and 0.93. This evidence concerns the gene NEFL and early-onset autosomal dominant Alzheimer disease.