In this study, plasma GFAP levels were compared between cognitively normal older adults at risk of Alzheimer’s disease with high PET-Aβ load (Aβ+) and those with low Aβ load (Aβ−) from the Kerr Anglican Retirement Village Initiative in Aging Health (KARVIAH) cohort (n = 134). The gene discussed is GFAP; the disease is early-onset autosomal dominant Alzheimer disease.