MAPT and Alzheimer disease: It is also important to consider that throughout the progression of Alzheimer’s disease, Aβ and tau pathology experience a complex and intricate association.119 Nonetheless, the exact mechanisms underlying this relationship remain incompletely understood, and it is unclear whether this association exists independently of the amyloid plaques.120 Astrogliosis contributes to several mechanisms directly linked to neurodegeneration, exacerbating its pathological features.