EPHX2 and hypertensive disorder: Recently, soluble epoxide hydrolase (sEH, EC 3.3.2.10) has been selected as a target for curing diversity diseases as its function is to convert functional epoxyeicosatrienoic acids (EETs) to less/no active dihydroxyeicosatrienoic acids (DHETs), which will influence various pathological responses such as inflammation, hypertension, and neurodegeneration.