Diosmin, through a ROS‐mediated mechanism, overexpression of caspases 9 and 3, p53, and downregulation of Bcl‐2 and MMP‐2,9 (matrix metalloproteinases 2 and 9) caused apoptosis in skin cancer cells (A431) (Paredes et al., 2018). This evidence concerns the gene TP53 and skin cancer.