Postmortem brain tissues of patients with neurodegenerative diseases were found to contain multiple UPR markers, such as phospho‐PERK (p‐PERK), activated ATF6, phospho‐inositol‐requiring enzyme 1 (p‐IRE1), phospho‐eukaryotic initiation factor 2 (p‐eIF2), binding immunoglobulin protein (BiP), and CHOP, which were associated with the accumulation of aggregated and misfolded proteins (Yarmohammadi et al., 2021). This evidence concerns the gene HSPA5 and neurodegenerative disease.