The microbiome composition of all 46 tumors from Cohort A has been profiled by 16S rRNA gene sequencing, and transcript levels of immunity-related genes in 41 tumors from this cohort have been analyzed by Nanostring in our earlier investigation.(16) Using additional tumor tissues from the same cohort, this study further conducted tumor metabolome profiling and immunohistochemistry using anti-CD8 and anti-FoxP3 antibodies. Here, CD8A is linked to neoplasm.