Hutchinson-Gilford progeria syndrome (HGPS) is a pediatric progeroid disorder caused by point mutations that optimize a cryptic splice-donor site in exon 11 of LMNA (the gene for prelamin A and lamin C), resulting in aberrant mRNA splicing and the production of a prelamin A transcript lacking the last 150 nucleotides of exon 11 (1, 2). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.