STXBP5 and amyotrophic lateral sclerosis: These were the TERRA repeat-containing RNA (UAGGGUUAGGGUUAGGGUUAGGG),61 found in human telomeres, and the four-repeat (GGGGCC)4 sequence (referred to as G4C2 hereafter), a hexanucleotide repeat found within the C9orf72 gene, whose expansion is associated with Amyotrophic Lateral Sclerosis (ALS),62 and to the BG4 antibody-bound mRNA G-quadruplexes containing genes Mark2 (5′-GAAGGGGAGGGGGCUGGGGGGGGGCAGGG-3′) and Stxbp5 (5’-GGGAAGGGAAGGGGAGUGGG-3’).