SERF family of proteins are rich in the amino acids E, D, R, and K, from whence comes their name, Small EDRK-Rich Factor.43 SERF proteins were initially isolated for their ability to accelerate amyloid formation in a C. elegans model of Huntington’s disease.40 Under normal growth conditions, we find that the human SERF2 protein is partially localized to the nucleus, diffusely staining in the cytoplasm, but is most enriched in the nucleolus, a membrane-less liquid-liquid phase separated compartment (Fig. 1a, b). This evidence concerns the gene SERF2 and Huntington disease.