In addition to the patient- and sibling - originated iPSCs, we used iPSCs produced from two sources by gene editing, including an OCRL KO line (690 KO) generated using CRISPR-Cas9 gene editing from a previously described control (690 Ctrl) that was unrelated to the LS subjects (Barnes et al., 2018; Ran et al., 2013). The gene discussed is OCRL; the disease is Leigh syndrome.