INS and asthma: The GSVA results demonstrated that the C1 cluster was mainly involved in immune diseases and metabolism-related pathways, such as asthma, drug metabolism other enzymes, glutathione metabolism, porphyrin and chlorophyll metabolism, while the C2 clusters were primarily enriched in cellular conduction-related pathways, such as neurotrophic signaling, the insulin signaling pathway, the GNRH signaling pathway, and ECM receptor interaction (Figure 3J).