IR is defined as the inability of the cells in the muscles, adipose tissue and liver to truly respond to insulin and is unable to remove glucose from the blood resulting in carbohydrate and lipid dysmetabolism [46].The observed ameliorative effect of OPEE and EX on T2DM-induced glucose and lipid dysmetabolism is consistent with the findings from our molecular docking that OPEE inhibits the activities of DPP-4 and LMPTP. Here, DPP4 is linked to type 2 diabetes mellitus.