To further observe and evaluate the correlation of these six genes with T2DM, LASSO regression analysis was executed based on the gene expression databases GSE25724, GSE118139, and GSE20966, wherein CLGN, ILF2 and IMPA1 were identified as critical biomarker genes for T2DM and therefore used for subsequent analysis (Figures 5B, C). The gene discussed is CLGN; the disease is type 2 diabetes mellitus.