TGFB1 and neoplasm: While it has multiple normal cellular functions, including effects on the cell cycle, motility, angiogenesis, and suppression of the initiation of some tumor types,17 TGF‐β can also serve as a driver of tumor progression by suppressing the host antitumor immune response, and by inducing tumor cell plasticity, a process rendering epithelial tumors more mesenchymal, stem‐like and resistant to immune and other therapies.17, 18