GBM, IDH-WT CR-mut tumors had significantly lower infiltration of M1 macrophage (q < .05), M2 macrophage (q < .01), and NK cells (P < .05) compared to CR-WT tumors, while regulatory T cells (Tregs) were increased (q < .0001; Figure 3A). Here, IDH1 is linked to glioblastoma.