This gene influences endothelin-1 expression, which plays a role in vascular tone and remodeling, implying a shared pathophysiological mechanism in vascular remodeling and arterial dissection susceptibility between FMD and SCAD [7]. Although FMD predominantly affects women, men can present with FMD, which can involve different vascular beds and manifest into life-threatening aneurysms and dissections [8]. Men with FMD tend to be predisposed to more severe manifestations of SCAD and higher rates of recurrence due to higher levels of coronary artery tortuosity [8]. Here, EDN1 is linked to spontaneous coronary artery dissection.