RUNX1 and acute myeloid leukemia: On the other hand, a higher frequency of mutations typically associated with AML has been reported, particularly those activating mutations in genes regulating cytokine receptor and RAS signalling (FLT3, JAK1, JAK3, KRAS, NRAS, IGFR1, IL7r, SH2B3, BRAF), those which affect genes coding for transcription factors (ETV6, RUNX1, GATA3, IKZF1, HOXA, EP300), as well as mutations which affect histone-modifying genes (EED, EZH2, SUZ12, DNMT3A).