T2DM: type 2 diabetes mellitus; DKD: diabetic kidney disease; GLP-1: glucagon-like peptide-1; UAER: urinary albumin excretion rate; AUC GLP-1: area under the curve of glucagon-like peptide-1; DN: diabetic nephropathy; UA: uric acid; RTGC: renal triglyceride content; ePV: estimated PV; HbA1c: glycated hemoglobin; LDL: low-density lipoprotein; UACR:  urine albumin-creatinine ratio; SBP: systolic blood pressure. The gene discussed is GCG; the disease is type 2 diabetes mellitus.