The prevalence of Coats-like RP approximates 5% of all RP patients [1-3]. We present a case of Coats-like RP whereby the patient demonstrates both clinical features of RP and exudative retinopathy with cystoid macula edema (CMO) that remains refractory to multiple intravitreal anti-vascular endothelial growth factor therapy (anti-VEGF) injections. Here, VEGFA is linked to chronic recurrent multifocal osteomyelitis.