Currently, multifarious forms of cell death are occurring during the development of IDD.19, 20, 21, 22, 23, 24 Ferroptosis is a newly identified iron-dependent and non-apoptotic programmed cell death that is related to lipid peroxidation.48, 49, 50 FSP1 is corroborated as an endogenous anti-ferroptosis protein to confer the induction by ferroptosis inducers when lacking GPX4.35 Here, AIFM2 is linked to intervertebral disk degenerative disorder.