SETBP1 and toxicity: The underlying includes congenital causes such as protein C or S deficiencies, acquired insults from endotoxins produced by gram-negative bacteria (Neisseria meningitidis), and enterotoxins or superantigens such as toxic shock syndrome (TSST-1), Staphylococcal enterotoxin B (SEB), and Staphylococcal enterotoxin C (SEC) produced by gram-positive bacteria (Staphylococcus aureus), and idiopathic triggers with poorly understood mechanisms [7,8].