Studies have shown that ENG expression is not limited to tumor vessels and increased endoglin expression has been confirmed in some neoplasms including melanoma, leukemias, renal cell carcinoma (RCC), endometrial, ovarian, prostate, breast cancers, and some subtypes of sarcomas [[29], [30], [31], [32], [33]]. This evidence concerns the gene ENG and hereditary clear cell renal cell carcinoma.