Central to our investigation is the role of VEGF-C, a pivotal regulator of lymphangiogenesis and lymphatic metastasis, through its interaction with VEGFR-3.13 Our data demonstrated differential expression patterns of VEGF-C and VEGFR-3 mRNA in MSI vs MSS gastric cancers, with lower expression levels observed in MSI ones. The gene discussed is VEGFC; the disease is gastric cancer.