Evidently, the differential distribution of CD8+ CXCR4+ T cells, with a more pronounced presence in MSS tumors and accessing peri-lymphovascular spaces as demonstrated by IHC, suggested a potential mechanism of immune evasion in MSS gastric cancers, where VEGF-C signaling might also play a role, as addressed above. This evidence concerns the gene CD8A and Marinesco-Sjogren syndrome.