FLT4 and neoplasm: Of them, VEGF-C enhances lymphangiogenesis and lymph node metastasis by binding to the receptor VEGFR-3 in an autocrine and paracrine manner.10-13 Apart from transporting tumor cells to lymph nodes, lymphatic endothelial cells lining lymphatic vessels actively participate in adaptive immunity, highlighting the dual role of VEGF-C signaling in promoting tumorigenesis both physically and immunologically.14-16