By breaking down subsets of T cells, we observed an increase in the effector memory RA (EMRA) population within the MSS group compared to the MSI group, indicative of a more differentiated and potentially exhausted T-cell phenotype in MSS tumors.34 This suggests that the immune response in MSS tumors may be characterized by a shift toward a less cytotoxic and more regulatory T-cell profile, potentially contributing to immune evasion.35 Higher expression of CXCR4, a chemokine receptor associated with T-cell egress within the TME, was observed in MSS tumors, as measured by flow cytometry. The gene discussed is CXCR4; the disease is Marinesco-Sjogren syndrome.