CXCL12 and neoplasm: Dynamics of CD8+ T cells within the TME are controlled by intricate mechanisms of recruitment, retention, and exit via lymphatic vessels.30 T-cell recruitment is heavily dependent on tumor-specific antigens, whereas tumor-associated lymphatic vessels sequester CD8+ T cells, increasing the probability of exit in a CXCL12-CXCR4-dependent manner, promoting CD8+ T-cell egress out of the TME.31–33 Our data demonstrate an increased overall CD8+ T-cell presence in the MSI cohort compared to the MSS counterpart, as consistently shown by flow cytometry and IHC analyses.