In mice subjected to myocardial ischemia‐reperfusion, the CD36 ligand azapeptide CP‐3(iv), increased circulating adiponectin levels, epididymal fat adiponectin gene expression, and transcriptional regulators (Pparg, Cebpb, Sirt1) after 6 h of reperfusion. The gene discussed is ADIPOQ; the disease is myocardial ischemia.