We performed small non-coding RNA-sequencing (RNA-seq) analysis of SOD1G93A and TDP43A315T models of ALS (spinal cord), a TauP301S model of FTD (hippocampus) and a parkin/POLG model of PD (substantia nigra), as well as their respective non-transgenic controls (Fig. 1). The gene discussed is PRKN; the disease is amyotrophic lateral sclerosis.