Up to 95% of PD cases are sporadic and 5% are genetic, with mutations mainly in alpha synuclein (SNCA), PARK2 (parkin), PARK7, PTEN induced kinase-1 (PINK1) and leucine-rich repeat kinase2 (LRRK2) (Tang et al., 2017). The gene discussed is PRKN; the disease is Parkinson disease.