Higher expression of 5′ tiRNA LysCTT in the SOD1 mouse model, as well as 5′ tiRNA ValCAC and 5′ tiRNA ValAAC in the TDP43 mouse model formed by ANG cleavage at the anticodon loop, suggests higher ANG activity in the mutant of the ALS mouse models. This evidence concerns the gene ANG and amyotrophic lateral sclerosis.