KLK8 and Anxiety: 2014) or the expression of proteins associated with the development of stress‐induced anxiety‐like behavior (e.g., FKBP51, KLK8, glucocorticoid receptor) (Attwood et al. 2011; Hadamitzky et al. 2018; Schmidt et al. 2012). Thus, it could be argued that FTY720 merely impairs locomotor activity rather than affecting anxiety‐like behavior. However, other studies have reported that FTY720 does not impact locomotor activity in wild type animals (Di Pardo et al. 2014; Li et al. 2023) or in disease conditions (Serdar et al. 2016).