MAPT and early-onset autosomal dominant Alzheimer disease: Traumatic brain injury (TBI), a prominent risk factor for Alzheimer’s disease (AD), induces tau acetylation at positions similarly acetylated in human AD brain, suggesting a potential molecular connection between TBI and AD.311 Targeting post-TBI-induced tau acetylation using acetylation inhibitors, such as salsalate, correlates with diminished neurodegeneration in humans.