MBD2 and cancer: UTX/KDM6A, a gene encoding a histone H3K27 demethylase, acts as a crucial cancer suppressor commonly mutated in human cancers.276 However, subsequent studies revealed that the demethylase activity of UTX is frequently independent of its role as a tumor suppressor.277–282 A recent study revealed that the chromatin regulatory activity of UTX in tumor suppression is rooted in its phase separation.283 The core intrinsically disordered region (cIDR) of UTX gives rise to condensates through phase separation, the loss of cIDR due to mutations is a key factor in nullifying tumor suppression.283