Their findings revealed that RBM20-deficient familial DCM hiPSC-CMs were more susceptible to stress, a vulnerability that could be therapeutically reduced by the β-blocker carvedilol and the Ca2+ channel blocker verapamil.369 This study paves the way for the development of therapeutic strategies to modify the progression of DCM. Here, RBM20 is linked to familial dilated cardiomyopathy.