Extensive hypermethylation of RNA observed in ALS spinal cord aligns with methylated TDP43 substrates, unveiling RNA modification targeting as an emerging avenue to regulate pathological protein phase transitions.314 Importantly, the investigator showed that TDP43-related neurotoxicity can be alleviated by knocking out the m6A reader YTHDF2,314 opening a potential new avenue for treating ALS. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.