Biancon et al. utilized high-resolution interactome to reveal that U2AF1 splicing factor mutations lead to an intensified stress response in myeloid malignancies.292 Cell lines carrying U2AF1 mutations and blasts derived from MDS/AML patients exhibited an increased SG response, indicating a new function for biomolecular condensates in adaptive oncogenic mechanisms (Table 4). The gene discussed is U2AF1; the disease is acute myeloid leukemia.