SPOP (speckle-type POZ protein) is a cancer inhibitor, and its mutations cause solid tumors.266–270 SPOP functions as a binding scaffold of the cullin3-RING ubiquitin ligase and attracts substrate through LLPS.271–274 Cancer-associated mutations in SPOP impair LLPS and are associated with a loss of function (Table 4).275. This evidence concerns the gene SPOP and cancer.