RBM20 is a splicing factor involved in cardiovascular development.185 RBM20 mutations cause the relocation of RBM20 from nuclear splicing speckles to cytoplasmic condensates, resulting in the sequestration of mRNA, polysomes, and cardiac cytoskeleton proteins.187 Wyles et al. investigated the impact of β-adrenergic stress on familial DCM using human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) from a patient with RBM20-related DCM. This evidence concerns the gene RBM20 and familial dilated cardiomyopathy.