WAS and Immunodeficiency: WASP mutations cause Wiskott–Aldrich syndrome (WAS), characterized by eczema, thrombocytopenia, immune deficiency, and thrombocytopenia.288 WASP regulates RNA splicing through a phase-separation process, and mutations in the WASP gene result in abnormal RNA splicing.289 Gene therapy using modified autologous CD34+ cells is an emerging treatment for WAS.