Huntington’s disease is caused by the expansion of a CAG trinucleotide repeat in the Huntingtin (HTT) gene.345–347 The HTT protein can assemble into liquid-like structures, which can transition into solid-like fibrillar assemblies within cells.348 This transition was further enhanced when the R200/205 methylation sites were modified.349 Therapeutic strategies aimed at lowering HTT levels are being developed to slow or halt the progression of Huntington’s disease.350–355 HTTRx, an antisense oligonucleotide developed to block HTT mRNA, reduces levels of mutant huntingtin protein. Here, HTT is linked to juvenile Huntington disease.