The accumulation of over-phosphorylated, tangled microtubule-associated protein tau (MAPT) is a defining feature of AD.334–341 An exciting recent discovery is that tau has a strong tendency to undergo LLPS.211 A randomized phase 1b clinical trial investigated the effect of BIIB080, an antisense oligonucleotide targeting MAPT, on tau synthesis in patients with mild AD. The gene discussed is MAPT; the disease is Alzheimer disease.