RNPC3 and amyotrophic lateral sclerosis: ALS stands as the predominant clinical manifestation of upper and lower motor neuron disease.223,224 A mounting body of evidence substantiates the concept of overlapping genetic and pathological features between ALS and FTD.225 The pathology of both ALS and FTD has been associated with environmental factors and an array of genetic changes, encompassing multiple point mutations in the LCR of proteins localized within RNP granules, as well as repeat expansions.