A growing body of evidence supports the hypothesis that baicalein exerts neuroprotective effects in PD due to its anti-apoptotic, pro-differentiation, and anti-oxidant properties.24–26 Based on the differential expression of Alox15 in the SN of different subtypes of PD rats, we further reported that baicalein, an Alox15 inhibitor,27,28 exhibited the most pronounced therapeutic effect on the Mix subtype of PD, especially in alleviating motor and tremor symptoms. This evidence concerns the gene MIXL1 and Parkinson disease.