The DEGs were further queried in the Drug Gene Interaction Database (DGIdb), a data mining platform for investigating the druggable genome for personalized treatment, to identify their interacting compounds.23 As shown in Fig. 5e–l, genes without reported effective PD therapeutic drugs were excluded, as well as genes that were inconsistent with RT-PCR verification results (Chrnb4, Aldh1a1, Drd2, Fkbp5). The gene discussed is ALDH1A1; the disease is Parkinson disease.