RUBCNL and amyotrophic lateral sclerosis: We have recently identified a new gene associated with ALS, called PACER (also called C13orf18, KIAA0226l or Rubicon-like/RUBCNL) [19], which positively regulates autophagosome maturation through interaction with the UVRAG complex and antagonizes RUBICON in stimulating activity of the VPS34 kinase [19, 20].