TARDBP and amyotrophic lateral sclerosis: In the murine model of ALS, mice that express the mutant version of 43 kDA of the protein TARDBP, it has been observed that high-fat foods extend their lifespan [51], a phenomenon that has also been observed in mice that express the mutant version of SOD1, when the activation of AMP-activated protein kinase (AMPK) is induced, a protein that acts as an energy sensor [52].