Although Yao et al. reported the role of ADAMTS16 in the activation of LAP-TGF-β1 in cardiac fibroblasts [50], the interaction between ADAMTS16 and LAP-TGF-β1 in tumor cells and the role of ADAMTS16 in EMT and metastasis in LUAD have not been clarified. This evidence concerns the gene TGFB1 and neoplasm.