The acetylation of FASN by lysine acetyltransferase 8 (KAT8) triggers FASN degradation through the ubiquitin‒proteasome pathway mediated by the E3 ubiquitin ligase TRIM21, leading to a reduction in de novo lipogenesis and tumor cell growth, whereas HDAC3 catalyzes FASN deacetylation [22]. Here, KAT8 is linked to neoplasm.