Both the biologically active form of dephosphorylated HMGCR and the HMGCR transcription are increased in the liver tissues of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) patients, suggesting severe cholesterol metabolism in patients with NAFLD [124]. The gene discussed is HMGCR; the disease is metabolic dysfunction-associated steatohepatitis.