Our study included 18 studies with 363 animals and showed that RES significantly improved cardiac function markers in the animal model of diabetic cardiomyopathy: LVEF (WMD = 17.88), LVFS (WMD = 8.77), and HW/BW(SMD=-2.92); anti-inflammatory and antioxidant markers also showed significant improvement: SOD (SMD = 4.53) and MDA(SMD=-5.07). Here, SOD1 is linked to diabetic cardiomyopathy.