While it is promising that the clinical validation of blocking γc cytokines by JAK3 inhibitor has been clinically validated in other autoimmune disorders such as IBD, pemphigus, and vitiligo.44–46 In our humanized lupus-like mouse model (GVHD), the detection of renal damage on day 28 revealed an accelerated disease progression marked by rapid weight loss and partial mouse mortality. This evidence concerns the gene JAK3 and systemic lupus erythematosus.