Various CD4+ T helper (Th) cell subsets, including Th1, Th2, Th17 and T follicular helper (Tfh) cells, along with their associated cytokines, as well as cytotoxic CD8+ T cells, are implicated in the immune pathogenesis of both SLE and LN.4 For enhanced efficacy in SLE treatment, consideration of T cells is imperative. The gene discussed is CD4; the disease is systemic lupus erythematosus.