IL7R and systemic lupus erythematosus: Soluble IL-7R levels correlate with SLE disease activity and anti-double-stranded DNA (anti-dsDNA) antibody concentration.19 IL-7 contributes to Th17 cell polarization in SLE, and the IL-7/IL-7R pathway destabilizes, creating conditions that override endogenous checkpoints against autoimmunity.20