Proinflammatory cytokines, i.e., IL-5 and IL-17F, which play vital roles in SLE, were reduced by 2D4 treatment (Fig. 5c), while anti-inflammatory cytokines, i.e., IL-10 and IL-13 were not affected (Fig. 5d). The gene discussed is IL13; the disease is systemic lupus erythematosus.