IL2RG and systemic lupus erythematosus: To explore the immunomodulatory role of upregulated CD132 in SLE disease, we purified CD4+ T cells and CD19+ B cells for probing the effects of CD132 blockade, using REGN7257, a pan CD132 blocking mAB.5 We interrogated the role of CD132 signaling in antibodies secreting by human B cells firstly.