KLF16 and neoplasm: In addition, immunohistochemistry (IHC) analysis using a tissue microarray (TMA) containing 108 BLCA specimens revealed that KLF16 protein was significantly upregulated in tumor tissues compared to adjacent noncancerous tissues (Fig. 1A, B), and high KLF16 protein levels were associated with worse progression-free survival (PFS) and cancer-specific survival (CSS) probabilities in patients with BLCA (Fig. 1C, D).