CXCR6 and neoplasm: In our analysis we focused on Ccl19, Cxcl9 and Cxcl16, because these chemokines were upregulated in BrM following PC blockade and have been previously implicated in the attraction of T cells to tumors.30, 34 The three cognate chemokine receptors CXCR3, CCR7 and CXCR6 were highly expressed on tumor-infiltrating CD8+ T cells in our preclinical model.