In line with enhanced infiltration of CD8+T cells into intracranial tumors following PC blockade, we observed an increase in gene expression for several T cell attracting chemokines in intracranial tumors of PC treated as compared with the control mice, including Ccl22, Ccl19 and Cxcl16, and a tendency for Cxcl9 (figure 5D). The gene discussed is CXCL16; the disease is pachyonychia congenita.