In vivo, specific downregulation of Mt1b in mouse liver significantly increased TG and TC levels and lipid accumulation (Supplementary Fig. S4E, F and Fig. 5E, F), aggravated liver fibrosis (Fig. 5G, H), and upregulated proinflammatory factors (Supplementary Fig. S4G), along with an increase in p-AKT expression (Fig. 5I). The gene discussed is AKT1; the disease is Hepatic fibrosis.