TDP-43 proteinopathy characterized by the cytoplasmic aggregation and nuclear depletion of TDP-43 is a common pathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD) (1, 4, 5). This evidence concerns the gene TARDBP and Alzheimer disease.