COL27A1, PRUNE2, MAEA, TBC1D3, GADD45B, ANXA8 and TSPY1 have been confirmed to play a pro‐resistant role in various cancers [24, 25, 26, 27, 28, 29, 30], which reflects the reliability of the hGeCKO library screening to some extent. Here, PRUNE2 is linked to cancer.